The Changing Face of Primary Care Research and Practice-Based Research Networks (PBRNs) in Light of the COVID-19 Pandemic
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* Hazel Tapp

## Abstract

The COVID-19 outbreak is a stark reminder of the ongoing challenge of emerging and reemerging disease, the human cost of pandemics and the need for robust research.1 For primary care, the advent of COVID-19 has forced an unprecedented wave of practice change. In turn, Practice-Based Research Networks (PBRNs) must rapidly pivot to address the changing environment and the critical challenges faced by primary care. The pandemic has also impacted the ability of PBRNs to deploy traditional research methods such as face-to-face patient and provider interactions, practice facilitation, and stakeholder engagement. Providers need more relevant, patient-centered evidence and the skills to effect change. These skills will become more important than ever as primary care practices evolve in response to the current COVID-19 pandemic and the disparities in health outcomes highlighted by COVID-19 and the global Black Lives Matter social movement for justice. Throughout this issue, authors detail the work conducted by PBRNs that demonstrate many of these evolving concepts. Articles explore how PBRNs can evaluate COVID-19 in primary care, the role of PBRNs in quality improvement, stakeholder engagement, prevention and chronic care management, and patient safety in primary care.

The COVID-19 outbreak is a stark reminder of the ongoing challenge of emerging and reemerging disease, the human cost of pandemics and the need for robust research.1 For primary care, the advent of COVID-19 has forced an unprecedented wave of practice change. In turn, Practice-Based Research Networks (PBRNs) must rapidly pivot to address the changing environment and the critical challenges faced by primary care. The pandemic has also impacted the ability of PBRNs to deploy traditional research methods such as face-to-face patient and provider interactions, practice facilitation, and stakeholder engagement. Key new areas for evaluation are the move to virtual visits, the health impact of COVID on practice staff, providers and patients (including racial disparities in outcomes), and practice business functions.

PBRNs have traditionally played a role in translation of research into practice, and more recently in the implementation and evaluation of quality improvement efforts.2⇓⇓⇓⇓⇓⇓–9 Since 2000, when Congress asked the Agency for Health care Research and Quality to identify and support primary care research,10 PBRNs have become a resource for accelerating the translation of research into practice with research generated by PBRNs shown to improve outcomes for patients and practices.11 PBRNs can also be thought of as able to help identify problems in daily practice, demonstrate whether treatments are effective and sustainable in real-world settings, and provide the “laboratory” for testing system improvements.12

Primary care physicians are more motivated than ever to incorporate evidence-informed decision making into everyday practice particularly in combination with patient engagement techniques such as shared decision making.13 Unfortunately, physicians are still hampered by the need for more relevant, patient-centered evidence and the need to acquire the skills to effect change. PBRNs incorporate community-engaged research, participatory implementation research, quality improvement and implementation science initiatives, continuing education, and the training of future generations of translational investigators.14 PBRNs use quality improvement and implementation science to inform and quantify improvements. In addition, sustained collaborations with providers, patients, and other relevant stakeholders such as local and national advocacy groups and community-based organizations are used to enhance the work of PBRNs.15

Currently, quality improvement and implementation science knowledge are still predominantly in the domain of researchers within PBRNs. These skills need to be translated to user‐friendly tools that are accessible and readily used by health care practitioners.16 Integration of new skills into practice is not easy because it often requires new kinds of relationships, conceptual frameworks, and even languages for clinicians, patients, researchers, academic institutions, and funding agencies. An emerging role for PBRNs is both traditional primary care research and collaborative learning communities that can identify, disseminate, and integrate new knowledge.9 These skills will become more important than ever as primary care practices evolve in response to the current COVID-19 pandemic and the disparities in health outcomes highlighted by COVID-19 and the global Black Lives Matter social movement for justice.

Throughout this issue, authors detail the work conducted by PBRNs, which demonstrate many of these evolving concepts. Articles explore how PBRNs can evaluate COVID-19 in primary care, the role of PBRNs in quality improvement, stakeholder engagement, prevention and chronic care management, and patient safety in primary care.

PBRNs are critical laboratories for studying the implementation of evidence-based practices in real-world settings. DeVoe et al17 describe how the current pandemic and primary care's response to it are among the most impactful natural experiments in our lifetime, presenting an opportunity to demonstrate PBRNs' power and value in supporting dissemination and implementation science. The collaboration between a community health care center PBRN and implementation scientists are being leveraged to evaluate how community health care centers across the country are responding to the COVID-19 pandemic. Researchers will use medical record data, telemedicine trainings, and qualitative interviews with practices over a 12-month period to identify practice adaptation to delivery of care.

Two articles illustrate how PBRNs facilitate advancements in quality improvement. Project ECHO (Extension for Community Health care Outcomes) uses case-based telementoring to support community clinicians to deliver best-practice care.18 McDonnell Elder et al19 describe how 1 PBRN has created a statewide network for ECHO programs. The PBRN facilitated a unique funding stream for the ECHO programs by partnering with payers and health care systems. Using examples of tobacco cessation, chronic pain and opioid prescribing, and diabetes management, the authors describe how the collaboration enhanced practice recruitment and retention and improve financial stability. Practice facilitation is an effective approach to implementing quality improvement in primary care. Regular facilitator-practice interactions are necessary for successful facilitation. Ye et al20 sought to identify practices facilitation barriers using a time series analysis to evaluate facilitation activities across multiple practices. While most facilitation activities occurred at regular practice-specific tempos, nearly all practices experienced at least 1 delay with facilitation, ultimately showing that number of facilitation delays correlated with lower intervention completion.

PBRNs frequently engage community members and clinic staff through community advisory boards and patient advisory councils.21 Additional strategies such as virtual solutions are now needed as PBRNs consider how to facilitate longitudinal engagement of stakeholders and the needs for virtual engagement created by COVID-19. Engster et al22 describe the creation of a virtual Parent Panel to engage parents remotely and use their input for child health research. The authors utilized an existing research study on pain management during routine child vaccinations to develop regular communication with a group of parents/patient stakeholders to provide feedback on research ideas. Although not meeting the definition of full community-based participatory research, given the large geographic area the PBRN serves, and barriers associated with bringing together in-person meetings, this strategy represents a pragmatic move forward in patient engagement, particularly in the light of COVID-19.

Additional approaches to patient engagement were described by Dickinson et al,23 where practice facilitation combined with patient engagement enhanced implementation of new models of care. Mungia et al24 discuss 7 years of dental practitioner engagement activities within a national dental PBRN. This network used a broad range of activities to engage community practitioners showing success in sustaining a high level of practitioner engagement in research that was relevant to everyday clinical practice. Nagykaldi et al25 describe using stakeholder partnerships to show community-wide health improvement across a rural PBRN. The Healthier Together study aimed to implement and evaluate a sustainable, community-based preventative care patient outreach model. Stakeholders included community-based wellness coordinators, primary care providers, county health departments, local hospitals, and health information exchange networks.

Prevention and chronic disease management is a large part of the work of primary care. Support and evaluation of prevention and chronic disease by PBRNs offers robust evaluation of current practice, new innovations and best practices.26,27 Krist et al28 point out that while barriers to preventive screening, such as colon cancer screening, are well documented, less is known about the relative importance of patient, clinician, health system, and communication factors associated with recommended screening, particularly for vulnerable populations. Based on the results of a large patient survey, the authors were able to show that having a long-term relationship with a primary care clinician and sharing decisions are key drivers to ensure evidence-based preventive care for underserved populations. In another study focusing on vulnerable populations, Heintzman et al29 examined potential disparities in care provided to Latino children compared with non-Hispanic white children and showed that in this multistate network of clinics, Latino children were less likely to have their asthma entered on their problem list than non-Hispanic white children, but otherwise did not receive inferior care. The authors suggest that asthma disparities experienced by this population may occur at other stages of care such as initial diagnosis or not actually filling the prescription medication filling, rather than at the stage of appropriate prescribing. Kwan et al30 used mixed-methods qualitative research to compare different models of diabetes shared medical visits. Researchers used surveys, interviews, and observation to assess practice contextual factors, such as practice size, location, payer mix, change and work culture, motivation to participate, and clinical and administrative capacity. Registries are foundational elements for the Chronic Care Model and the Patient-Centered Medical Home.31 Previous research has demonstrated that registries are effective for improving clinical guideline adherence for care of patients with type 2 diabetes. However, registry implementation has typically relied on intensive support (such as practice facilitators) for practice change and care improvement. Sabo et al32 showed that a remotely delivered, low-intensity peer mentoring intervention can support the use of diabetes registries in primary care, reducing the intensity of support needed. Primary care obesity management has many barriers for providers including the reality of managing patients' expectations. Brooks et al33 used a qualitative approach to discover what motivated primary care clinicians to take part in an obesity research intervention. Providers felt that the research project provided a concrete plan to address their ongoing clinical care need for effective obesity treatment and management, offered help to frustrated physicians who felt a deep professional duty to care for all their patients' problems, and because it demonstrated their commitment to improving the health of the broader community. Team-based approaches to disease management continue to be important areas of study. Clinical pharmacists provide important services in patient care and have the time to devote to more granular dietary and medical management. Norton et al34 showed that collaboration of pharmacists and physicians in the primary care setting is associated with improved diabetes outcomes and substantially reduces costs.

Patient safety in primary care is a priority. Issues such as overprescribing medications, diagnoses, transitions, referrals, and inappropriate testing are emerging areas of concern.35 Lai et al36 discovered that providers and patients prefer function-based conceptualizations such as not causing harm and viewing patients' needs holistically, that better reflect front line personnel and patients' experiences rather than domain-based conceptualizations, such as overprescribing medications, which are favored by experts.

Going forward, the physical, psychological, and societal consequences of COVID-19 will need to be considered in all aspects of primary care and associated practice-based research needs.

## Acknowledgments

The author would like to acknowledge the assistance of Sylvia Tapp in the preparation of this manuscript.

## Notes

*   *Funding:* Funding for this work was supported by Atrium Health.

*   *Conflict of interest:* The author has no conflicts of interest.

*   To see this article online, please go to: [http://jabfm.org/content/33/5/645.full](http://jabfm.org/content/33/5/645.full).

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