The epithelium of the gastrointestinal tract undergoes constant rapid renewal. Although this
phenomenon was predicted nearly 90 years ago on the basis of mitotic counts, 1 an …

: Before the recent understanding of the central importance of Helicobacter pylori in the
pathogenesis of peptic ulcer disease, smoking had been regarded as an important contributor to …

We studied the effect of esophageal inflammation on lower esophageal sphincter (LES)
pressure in cats by measuring LES pressure and taking mucosal biopsies before and after the …

The pathogenesis of peptic ulcer disease is multifactorial, including the effects of Helicobacter
pylori, gastric acid, pepsin, gastroduodenal motility, smoking and nicotine, and the …

Mucosal biopsies from human rectum were cultured in vitro using a simple organ culture
system. Light microscopy consistently revealed good preservation of rectal mucosa in biopsies …

Bile salts break the gastric mucosal barrier. To explain this, the suggestion has been made
that bile salts may disrupt surface epithelial cell membranes or break the tight junctions …

To determine the effect of smoking on gastroduodenal mucosal prostaglandin synthesis,
endoscopies were done after an overnight fast on 10 nonsmokers, 12 active smokers who …

The constant rapid renewal of the epithelium of the gastrointestinal (GI) tract is important in
the development of neoplasms that are derived from the epithelium as well as in maintaining …

Epithelial cell proliferation and migration were studied in cultured mucosal biopsies of the
rectum from 14 patients with ulcerative colitis (DC) and eight normal volunteers. More than …

We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferaton by
feeding rats aspirin in the drinking water. A control group of rats received plain water. At the …