The discovery of drug-like molecules that bind pockets in proteins that are not present in
crystallographic structures yet exert allosteric control over activity has generated great interest in …

TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves
activity against new drugs. However, functional changes are not easily explained by …

Proteins from thermophiles are generally more thermostable than their mesophilic homologs,
but little is known about the evolutionary process driving these differences. Here we …

We have developed a method for the rapid and unambiguous identification of sequences of
hit compounds from one-bead-one-compound combinatorial libraries of peptide and peptoid …

Protein stabilization is fundamental to enzyme function and evolution, yet understanding the
determinants of a protein’s stability remains a challenge. This is largely due to a shortage of …

Allosteric drugs, which bind to proteins in regions other than their main ligand-binding or
active sites, make it possible to target proteins considered “undruggable” and to develop new …

Proteins are dynamic molecules that undergo conformational changes to a broad spectrum
of different excited states. Unfortunately, the small populations of these states make it difficult …

Proper folding of proteins is critical to producing the biological machinery essential for cellular
function. The rates and energetics of a protein’s folding process, which is described by its …

Home blood pressure monitoring provides important diagnostic information beyond in-office
blood pressure readings and offers similar results to ambulatory blood pressure monitoring. …

Tabtoxinine-β-lactam (TβL) is a phytotoxin produced by plant pathogenic strains of
Pseudomonas syringae. Unlike the majority of β-lactam antibiotics, TβL does not inhibit …