Since its publication in the Journal in 1961, “The Ecology of Medical Care,” by White et al., 1
has provided a framework for thinking about the organization of health care, medical …

We describe a strategy for producing human monoclonal antibodies in mice by introducing
large segments of the human heavy and κ light chain loci contained on yeast artificial …

We constructed two megabase-sized YACs containing large contiguous fragments of the
human heavy and kappa (κ) light chain immunoglobulin (Ig) loci in nearly germline …

The major impediment to the development of murine monoclonal antibodies (mAbs) for therapy
in humans has been the difficulty in reducing their potential immunogenicity. XenoMouse…

INTRODUCTION of DNA fragments, hundreds of kilobases in size, into mouse embryonic
stem (ES) cells would greatly advance the ability to manipulate the mouse genome. Mice …

Light olefins (C3-C6) can be converted to a mixture of higher molecular weight olefins via a
sequence of acid-catalyzed-shape-selective polymerization and isomerization reactions over …

Background Many members of families with inherited long-QT (LQT) syndrome have
mutations in HERG, a gene encoding a cardiac potassium channel that is modulated by …

Background: The epidemiology, risks, and outcomes of errors in primary care are poorly
understood. Malpractice claims brought for negligent adverse events offer a useful insight into …

■ OBJECTIVES A usual source of care is associated with better health outcomes.
Dissatisfaction among family physicians and general practitioners (FP/GPs) may compromise the …

Making evidence from scientific studies available to clinical practice has been expected to
directly improve quality of care, but this expectation has not been realised. The notion of …